Conserved and divergent expression dynamics during early patterning of the telencephalon in mouse and chick embryos.

ARTÍCULOS CIENTÍFICOS

TÍTULO

Conserved and divergent expression dynamics during early patterning of the telencephalon in mouse and chick embryos.

AUTOR

Muley VY, López-Victorio CJ, Ayala-Sumuano JT, González-Gallardo A, González-Santos L, Lozano-Flores C, Wray G, Hernández-Rosales M, Varela-Echavarría A.

Prog Neurobiol. 2020 Mar;186:101735. doi: 10.1016/j.pneurobio.2019.101735

Researchers at INB-UNAM sequenced and analyzed RNA populations of mouse and chick during the early stages of embryonic brain development and discovered approximately 3000 genes that regulate telencephalon development. Many of chromatin-associated epigenetic and transcription regulators showed high expression and previous studies associated them to autism, intellectual disabilities, and mental retardation. These observations suggest a link between telencephalic development and autism spectrum disorders.

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